Si toma diazepam junto con otros medicamentos para controlar las convulsiones, no deje de tomar diazepam sin consultarlo antes con su médico, incluso si experimenta efectos secundarios como cambios inusuales en el comportamiento o estado de ánimo.
butabarbital will reduce the level or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
As a consequence of its somewhat lengthy length of action, and proof of safety and efficacy, diazepam is favored more than other benzodiazepines for that treatment method of individuals experiencing average to severe Liquor withdrawal.
verapamil will improve the level or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
If any withdrawal reaction develops, look at pausing taper or raising dose to past tapered dosage amount; subsequently lessen dose additional slowly but surely
mitotane decreases levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Mitotane is a strong inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for probable dosage adjustments.
Rebound stress and anxiety, much more extreme than baseline stress, is usually a common withdrawal symptom when discontinuing diazepam or other benzodiazepines.[80] Diazepam is as a result only proposed for brief-phrase therapy click here at the bottom attainable dose owing to risks of critical withdrawal complications from low doses even right after gradual reduction.
Lonafarnib might raise the AUC and peak focus of CYP2C19 substrates. If coadministration unavoidable, monitor for adverse reactions and lessen the CYP2C19 substrate dose in accordance with its authorized item labeling.
Lencapavir (a average CYP3A4 inhibitor) could enhance CYP3A4 substrates initiated inside of nine months soon after previous SC dose of lenacapavir, which may increase probable threat of adverse reactions of CYP3A4 substrates.
topiramate will decrease the extent or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
medicines was carried out ahead of the in-depth expertise in the GABAA receptors. However, structure–action connection
teduglutide increases amounts of diazepam by Other (see comment). Use Caution/Observe. Comment: Teduglutide may possibly improve absorption of concomitant PO remedies; warning with with medicines demanding titration or Those people which has a slender therapeutic index; dose adjustment might be required.
nifedipine will enhance the degree or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
prednisone will reduce the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.